Although sudden cardiac death is considered to be a major mode of death in patients with heart failure, no satisfactory medical therapy is available for its prevention. Since over activation of sympathetic nervous system is invariably seen in subjects with high risk for sudden ca [....] » Read More
Nanomedicine has already provided dozens of FDA approved products improving the lives of billions. Most notably, nanomaterials have been used to develop vaccines for COVID, improved spinal implants, anti-infection materials without using antibiotics, and numerous drug delivery ve [....] » Read More
Aortic root replacement is an operation that requires resection of diseased aortic sinus tissue. Patients requiring aortic root replacement include those with combined aortic valve degeneration and aortic pathology, such as bicuspid aortic stenosis and root aneurysm. Other indica [....] » Read More
Heart failure is a serious clinical syndrome with symptoms and signs provoked by a structural and functional cardiac abnormality, and coupled with elevated natriuretic peptide levels and evident pulmonary or systemic congestion. Regardless of outstanding improvements in the manag [....] » Read More
Introduction: Myocardial bridging is congenital coronary anomaly in which a segment of an epicardial coronary artery takes a tunnelled course under a bridge of the myocardium. This segment is compressed during systole, resulting in the so-called “milking effect” [....] » Read More
Arterial stiffness has emerged as a prominent marker of risk for cardiovascular disease. Few studies are interested in predicting symptomatic or asymptomatic arterial stiffness from hemodynamics and biomechanics parameters. Machine learning models can be used as an intelligent to [....] » Read More
Aim: To determine significance of patient-prosthesis mismatch (PPM) (indexed effective orifice area < 1,2 cm²/m²) after combined mitral-aortic valve replacement (MAVR) + TV`s plasty (TV) in pts with small cavity of left ventricle (SCLV) (end-diastolic volume (ED [....] » Read More
Aim:To research possibilities of surgical treatment of poststenotic aneurysms of ascending aorta (PAAA) by different methods. Methods: During 2000-2023 yy 454 patients (pts) with aortic stenoses (AS) and PAAA were consecutively operated in Inst [....] » Read More
Objective. To determined possibillities of left atrium (LA)`s reduction by original method of arch plasty of LA (APLA) during mitral valve replacement (MVR) for isolated mitral valve disease (MVD). Methods. During 2005 – 2022 yy. 454 adult patients (pts) with [....] » Read More
Objective: To present analysis of retrograde crystalloid cardioplegia during combined valve pathology of mitral-aortic-tricuspid valve disease (matvd) . Materials and Methods: During 2009-2023 yy 529 patients (pts) with (MATVD) were operated in Institute by CPB [....] » Read More
Objective: To determined possibillities of correction of the left parts of the heart by preservation of MV`s apparatus and concomitant reduction of left atrium (LA) during correction of combined mitral-aortic-tricuspid valve diseases (CMATD). Methods: During 01.01.2006-0 [....] » Read More
Objective: To analyzed main problems in surgery of mitral valve diseases (MVD) complicated by left atrium`s massive thromboses (LAMT) (thromboses more than 1/3 of left atrium`s volume). Materials And Methods 336 adult patients (pts) with MVD comp [....] » Read More
Objective. To determined possibillities of left atrium (LA)`s reduction by original method of triangular plasty of LA (TPLA) during mitral valve replacement (MVR) for isolated mitral valve disease (MVD). Methods. During 2005 – 2022 yy. 725 adult patients (pts) [....] » Read More
Objective: To present analysis of pharmacological supporting of conditions of coronary artery and myocardium (pre and postcondition) during combined mitral-aortic valve replacement (MVAR) + TV`s plasty . Materials and Methods: During 2015-2022 y 203 patients (p [....] » Read More
Dyslipidaemia comprises of abnormal lipid components and refers mainly to increased levels of LDL, non HDL particles and triglycerides while decreased levels of HDL Dyslipidaemia is a common and independent modifiable risk fac [....] » Read More
WHO considers diabetes mellitus (DM) to be a pandemic that has spread throughout the world. In some countries, this epidemic reaches >8% of the adult population, and in 20 years the frequency is expected to increase to 30-50%. Prospective studies have demonstrated that patient [....] » Read More
Throughout the body blood flow is regulated by vascular tone secondary to local or neurologic control. However, in the musculoskeletal system, the effects of muscular contraction can lead to augmentation of restriction of local blood flow. While repetitive muscle contraction incr [....] » Read More
Metabolic Dysfunction and Metabolic Syndrome birthed with visceral adiposity, and Insulin resistance has wide spread implications. From a bed of inflammation at the visceral adipose tissue core, RAAS activation and constricted vascular micro-perfusion. To hyperinsulinemia and vol [....] » Read More
Hypertensive?HTN? is one of the risk factors for cardiovascular disease, and exercise has a protective effect on the heart. However, the mechanism by which exercise affects HTN-induced myocardial damage is unclear. In this study, the exercise response model of HTN myocardial inju [....] » Read More
Background: The triglyceride-glucose (TyG) index, which is a reliable substitute indicator for insulin resistance, has been considered an independent risk factor for long-term outcomes in patients with cardiovascular disease. However, at present, only a limited number of stu [....] » Read More
Background: Acute kidney injury (AKI) is a common complication following coronary artery bypass grafting (CABG) surgery, with an incidence of 30-60%, significantly impacting both short-term and long-term mortality. In patients undergoing CABG, severe multivessel coronary art [....] » Read More
Objective: Currently, atherosclerosis and hyperuricemia remain among the most challenging metabolic disorders globally. Extensive epidemiological surveys and clinical studies have indicated a potential pathological link between hyperuricemia and atherosclerosis, even suggesting a [....] » Read More
Objective: Based on the phenomenon of elevated blood uric acid in patients with clinical adriamycin cardiac injury, to explore the effect of high uric acid on the progression of adriamycin cardiotoxicity. Methods: Adriamycin cardiotoxicity mouse model was established by intraper [....] » Read More
Background: Lipoprotein(a) has been implicated as a pathogenic risk factor for atherosclerosis and its complications. The triglyceride-glucose (TyG) index, a novel surrogate marker for insulin resistance (IR), has been identified as an independent predictor of adverse cardia [....] » Read More
Background: Postoperative atrial fibrillation (POAF) is the most common complication following coronary artery bypass grafting (CABG), which increases the risk of stroke and mortality, prolongs the length of hospital stays, and leads to higher healthcare costs. Structural ch [....] » Read More
Management of stress by yogic practices like Surya Namaskar, Pranayama and Meditation. Medical education includes the strenuous course load and hectic schedule, most students have a lack of time to take care of health and relaxation techniques. Yoga is gaining prominence in impro [....] » Read More
Introduction: Numerous investigations examining fenestration in the Fontan procedure have presented inconsistent findings regarding its effectiveness in improving surgical outcomes. The objective of this meta -analysis is to contrast the early results of fenestrated versus non-fe [....] » Read More
A new coronavirus infection identified by the World Health Organization Committee as COVID-19 ("Coronavirus disease 2019") with the official name of the causative agent of infection – SARS-CoV-2. Some patients develop hypercoagulation syndrome with thrombosis [....] » Read More
Aortic stenosis is the most common valvular disease and has a poor prognosis without surgical treatment. The use of sutureless valves (SV) has been emerging as a promising surgical option in certain patient populations especially in the elderly, frail and in redo cardiac procedur [....] » Read More
Background: Arrhythmias are one of the most serious disorders in cardiovascular and clinical medicine. Understanding the pathogenesis and mechanisms of arrhythmias is very advantageous to the appropriate management and treatment of all arrhythmia types. The “Graded phenomen [....] » Read More
Chronic pain is defined as persistent pain for more than three months and can be classified as primary with no known etiology, or secondary pertinent to a pathological process and specific clinical diagnosis.In previous studies, we observed that it directly impacts cardiac rehabi [....] » Read More
The pursuit of cardiovascular wellness is of paramount global concern, touching the lives of many individuals and societies. Understanding the intricate interplay between economics and behavior in the context of heart health is pivotal for crafting effective strategies to mitigat [....] » Read More
Exercise is an important factor of rehabilitation in heart failure patients, improving several indicators of disease prognosis and functional capacity. The aim of the present study was to examine the effect of a cardiorespiratory rehabilitation program on the physical and mental [....] » Read More
Increased physiological demands coupled with haemodynamic changes occurring during pregnancy pose a unique and significant challenge to the cardiovascular system. Pregnant women are at risk of suffering from the exacerbation of pre-existing cardiovascular disease (CVD) as w [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Telehealth is a growing field of importance, but the loss of comprehensive physical exam data creates barriers to managing complex heart failure patients. Innovative digital tools such as VPExam Virtual Care combine augmented reality guidance of video acquisitions with Blue [....] » Read More
Recommendations for the primary prevention of cardiovascular disease (CVD) vary by global region. This variability occurs by nature of different practice guidelines being put forth by separate regional cardiology societies, such as The American College of Cardiology/American Hear [....] » Read More
It is known that oxidized low density lipoproteins (oxLDL) interaction with the cluster of differentiation 36 (CD36)/SR-B2, a scavenger membrane protein, at the surface of macrophages, leads to an internalization of oxLDL in the cells. During atherosclerosis development, an exces [....] » Read More
Introduction: Congestive heart failure (CHF) is an increasingly prevalent terminal illness in a globally aging population. Despite optimal medical management, prognosis remains poor – a fact seldom communicated to patients and/or their families. Evidence suggests [....] » Read More
Peripheral artery disease (PAD) is a cardiovascular disease affecting more than 8.5 million Americans over the age of 40 years and is prevalent in the geriatric cardiology population. PAD is a manifestation of systemic atherosclerosis, characterized by atherosclerotic blockages o [....] » Read More
Cardiovascular disease is the #1 killer of adults worldwide, with low-socioeconomic urban patients more severely affected. Social Determinants of Health (SDOH) such as community violence, elements of the built environment, income, literacy, and access to food and pharmacy a [....] » Read More
In this study, we explore the possibility that ECG recordings belong to class of multifractal process for which a large number of scaling exponents are required to characterize their scaling structures. We use the BIDMC Congestive Heart Failure database including long term ECG re [....] » Read More
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While cardiovascular disease remains the most common cause of death worldwide, clinical approaches to the management of common cardiovascular conditions such as heart failure, coronary artery disease, and atrial fibrillation vary widely from institution to institution and from pr [....] » Read More
Most palpitations in pregnancy are benign and usually occur due to atrial or ventricular premature complexes. Careful consideration should be given to the gestation stage and the patient's hemodynamic state. In hemodynamically stable pregnant patients with acute onset of [....] » Read More
Background: The donkey pericardium is considered to be a good candidate material for use in the manufacture of percutaneous heart valves based upon its thinness, its low cellularity and its undulating collagen bundles and laminates. Decellularization represents an avenue worth ex [....] » Read More
Background: The donkey pericardium is considered to be a good candidate material for use in the manufacture of percutaneous heart valves based upon its thinness, its low cellularity and its undulating collagen bundles and laminates. Decellularization represents an avenue worth ex [....] » Read More
In the rapidly evolving landscape of healthcare, the role of Medical Affairs (MA) is increasingly pivotal in the successful launch of new molecular entities (NMEs). This abstract delves into the innovative approaches that are revolutionizing MA, specifically focusing on how these [....] » Read More
Background: This study aims to evaluate the efficacy, safety, and long-term effects of sacubitril/valsartan in treating hypertrophic cardiomyopathy using a hypertrophic cardiomyopathy rat model and in vitro cardiomyocytes. Hypertrophic cardiomyopathy presents a challenge in cardi [....] » Read More
Background: It is well known that conventional right ventricular (RV) pacing results in left ventricular dyssynchrony. Approximately 30% of patients with normal baseline ejection fraction (EF) and >40% of RV pacing will go on to develop cardiomyopathy and heart failure. Conduc [....] » Read More
Title : Managing total chronic coronary occlusion: Noninvasive External Counterpulsation (ECP) induces collaterogenesis, relieving ischemia, as demonstrated by quantitative PET myocardial perfusion imaging: ECP is a cost-effective alternative to high risk PCI
Michael E Merhige, State University of NY at Buffalo, United States
Background: External Counter Pulsation (ECP) is an FDA approved, noninvasive, treatment for patients with refractory angina, who are not candidates for low-risk interventional revascularization, such as those with chronic total coronary occlusion (CTO). ECP uses sequentially [....] » Read More
Title : Novel signaling pathways and therapeutic options for pulmonary hypertension
Yong Xiao Wang, Albany Medical College, United States
Pulmonary hypertension (PH) is a common and devastating lung disease. The current primary medications for this disease are to use non-specific vasodilators, but patients do not always respond well to non-specific vasodilators. Voltage-dependent potassium channels and store-operat [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model to be set up through biodesign-inspired and biotech-driven translational applications and cardiology-related marketing to secure the human healthcare and biosafety
Sergey Suchkov, N. D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare ser-vices, namely Personalized and Precision Medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the re [....] » Read More
Title : How do nutraceuticals protect against heart disease?
Dipak P Ramji, Cardiff University, United Kingdom
Atherosclerosclerotic cardiovascular disease (ACVD) is responsible for a third of all global deaths. Although a reduction in morbidity and mortality from ACVD has been achieved recently by lifestyle changes and pharmaceutical intervention, this is expected to reverse in the futur [....] » Read More
Title : Cuffless blood pressure monitoring using multiple artificial intelligence models
Prabode Weebadde, Purdue University, United States
In the U.S., every year, about 800,000 people die due to cardiovascular diseases (CVD) or diseases related to the heart and blood vessels. Of those 800,000, 650,000 deaths were related to the heart, and 150,000 were related to blood vessels. To put it in another perspective, ever [....] » Read More
Title : The cardiovascular hospitalist, a paradigm shift: Impact of specialty hospitalists on clinical, financial, and operational care delivery in a large us health care institution (Intermountain Health)
Blake I Gardner, Intermountain Health, United States
Intermountain Health is a large integrated healthcare institution in the western United States that prioritizes value-based care, even at times when it appears contrary to regional and national payment models. Because of this focus, Intermountain Health has been at the forefront [....] » Read More
Title : Antibodies with functionality as a new generation of translational tools designed to monitor autoimmune myocarditis at clinical and subclinical stages
Sergey Suchkov, N. D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs) with a capacity to hydrolyze the antigenic (Ag) substrate. In this sense, proteolytic Abs (Ab-proteases) represent Abs to provide proteolytic effects. Autoimmune myocarditis (AIM) can be defined as the autoimmune i [....] » Read More
Title : Multidisciplinary approach to cardiovascular patient
Lusine Harutyunyan, Adventist Health, United States
Importance on multidisciplinary approach to cardiovascular patients- specifically ASCVD and CHF groups. Financial and socioeconomic burden of cardiovascular disease and ways to improve patient outcomes and patient satisfaction. Will discuss ways to standardize medical care. ACC/A [....] » Read More
Title : Modeling human heart development and congenital disease using an iPSC-based 3D bioprinted model of embryonic human heart
Vahid Serpooshan, Emory University and Georgia Institute of Technology, United States
Human cardiogenesis is a finely orchestrated process that involves dynamic genetic and morphological changes. However, the cellular and microenvironmental processes underlying the human heart development remain obscure, due to limited access to human heart in utero and the lack o [....] » Read More
Title : IV Iron in heart failure -A Quality Improvement Project (QIP)
Qazi Naeem ur Rehman, Wirral University Teaching Hospital NHS Foundation Trust Wirral, United Kingdom
Introduction: Heart failure affects more than 64 million people worldwide and causes significant morbidity and mortality. The prevalence of iron deficiency (ID) can reach up to 59% in patients with heart failure. ID is an independent predictor of outcomes and major contributor to [....] » Read More
Title : Unlocking the cardiac vector theory and einthoven equilateral triangle model: A paradigm shift or a major transition in ECG interpretation?
T Rajini Samuel, Shri Sathya Sai Medical College and Research Institute, India
Introduction: Electrocardiogram (ECG) has offered immense clinical value for more than a century yet its interpretation remains an arduous task and ECG phobia develops in some of the junior doctors and staff nurses often seeking the help of medical experts in that field. Ei [....] » Read More
Title : Anesthetic management of a patient with dilated cardiomyopathy posted for hernioplasty
Vivek Vaibhav, Rama Medical College Hospital and Research Center, India
Dilated cardiomyopathy (DCM) is a myocardial disease characterised by ventricular dilatation and global myocardial dysfunction (ejection fraction < 40%). Patients usually present with symptoms of biventricular failure, e.g. fatigue, dyspnoea, orthopnoea, ankle oedema A [....] » Read More
Title : Erythrocytes and distribution of the information in the human body
Merab Beraia, Tbilisi State University, Georgia
At the beginning of blood flow, red blood cells (RBCs) align in the central plane of the vessels. In capillaries, RBCs change from a biconcave disk to a parachute shape and as blood moves from the arterial to the venous end, hemoglobin in erythrocytes alters magnetic susceptibili [....] » Read More
Title : Harm reduction in smoking: What does the scientific evidence say?
Cristina Milagre Quadros Borges, Hcor- Heart Hospital of Sao Paulo, Brazil
Smoking is considered a chronic disease, caused by chemical dependence of nicotine. This is highly addicting, it in the brain system, it infuences our emotions increases the feeling of pleasure/humor and reduces the anxiety. In a planet with about 8 billion people, around 1 [....] » Read More
Title : Ambulatory blood pressure monitoring in patients with diabetic nephropathy
Samia Barbouch, Charles Nicolle Hospital, Tunisia
Diabetic nephropathy (DN) is the main cause of renal failure worldwide. DN is often associated with high blood pressure (BP), and these two pathologies seem to maintain each other. However, the impact of this nephropathy on the fluctuations of blood pressure is not well establish [....] » Read More
Title : Anti-atherogenic actions of punicalagin and its metabolites
Faizah Albalawi, Cardiff University, United Kingdom
Atherosclerotic cardiovascular disease (ACVD) is responsible for most global morbidity and mortality, contributing to a third of all deaths worldwide. ACVD is a low-grade chronic inflammatory disorder of the vasculature that is associated with build-up of lipids, cellular debris [....] » Read More