Title : Exploring the pathological connection and clinical management of hyperuricemia and atherosclerosis: A literature review-based investigation
Abstract:
Objective: Currently, atherosclerosis and hyperuricemia remain among the most challenging metabolic disorders globally. Extensive epidemiological surveys and clinical studies have indicated a potential pathological link between hyperuricemia and atherosclerosis, even suggesting a bidirectional causative relationship. However, the precise nature of these connections has not been definitively established. Thus, in this review, we comprehensively examine and discuss the bidirectional relationship between hyperuricemia and atherosclerosis.
Methods: Employing a literature review approach, we discuss the bidirectional pathological connections between hyperuricemia and atherosclerosis, along with clinical prevention and treatment.
Results: This review highlights mechanisms through which atherosclerosis is influenced by hyperuricemia, including reduced bioavailability of nitric oxide due to oxidative stress induced by uric acid and xanthine oxidoreductase, inflammasome activation, effects on lipid metabolism and cholesterol transport, all of which, in turn, accelerate the occurrence and progression of atherosclerosis. In terms of clinical management, current strategies primarily involve pharmacotherapy and lifestyle interventions. Pharmacological treatments encompass uric acid synthesis inhibitors, cholesterol-modulating agents, and more. Lifestyle interventions comprise a balanced diet, moderate exercise, smoking cessation, and alcohol moderation.
Conclusion: The relationship between hyperuricemia and atherosclerosis is intricately intertwined. Early assessment and treatment of hyperuricemia are imperative to prevent atherosclerosis, and individuals with atherosclerosis should adopt dietary measures to prevent elevated uric acid levels.
Keywords: Uric Acid, Atherosclerosis, Prevention and Treatment, Pathological Connection
Audience Take Away Notes:
- From the perspective of literature review, the bidirectional pathological link between hyperuricemia and atherosclerosis and clinical prevention and treatment were comprehensively and systematically discussed
- Summarize the pathological link between hyperuricemia and atherosclerosis, including inflammasome activation, oxidative stress, dysbacteriosia, lipid metabolism abnormalities, etc., from clinical research and epidemiological research to drug research, and finally return to clinical prevention and treatment
- Through the pathological association analysis of hyperuricemia and atherosclerotic diseases, this paper provides new directions and ideas for the clinical prevention and treatment of the two diseases, and at the same time, it also warns against the inertness of clinical treatment of asymptomatic hyperuricemia patients
