Direct myocardial transplantation of HFDSCs (Fetal Liver Stem Cells) by open-chest surgical procedure was performed in 10 patients with HF due to nonischemic, nonchagasic dilated cardiomyopathy. All 10 patients survived the operation. At 40 months, the mean (+/-SD) NYHA class dec [....] » Read More
Lipoprotein (a) [Lp(a)] is a unique lipoprotein particle composed of an LDL-like particle linked to a glycoprotein called apolipoprotein(a). Elevated levels of Lp(a) have been identified as an independent risk factor for cardiovascular disease, including atherosclerosis, heart at [....] » Read More
Background: Direct-acting oral anticoagulants (DOACs) are absorbed in the upper gastrointestinal tract, but patients with gastrointestinal disease were not included in the Phase II and III drug investigations. This report details a patient with altered gastrointestinal anatomy an [....] » Read More
Kinetic modeling is an essential method in understanding the dynamic interactions of biological systems, particularly in the context of cardiovascular physiology. This study delves into the application of kinetic modeling to elucidate the heart's function as a critical input [....] » Read More
Although the regulation of cholesterol homeostasis in the body has been extensively studied, there is little information on how this regulation takes place in the brain. Cholesterol does not cross the blood-brain barrier; therefore cholesterol metabolism in the brain is independe [....] » Read More
Chronic pain is defined as persistent pain for more than three months and can be classified as primary with no known etiology, or secondary pertinent to a pathological process and specific clinical diagnosis. In previous studies, we observed that it directly impacts cardiac rehab [....] » Read More
Cardiovascular diseases (CVD) correspond to the main cause of death worldwide in both sexes. 1/3 of deaths from all causes affects men and women in all age groups. They represent more than bouble the number of deaths from all neoplas associated. Increase in the prevalence of CVD [....] » Read More
Background: Coronary artery disease (CAD) results from the obstruction of blood supply to the heart. Angioplasty is a common intervention for managing CAD, supplemented by supportive and preventive therapies. Modifiable risk factors for CAD include hypertension, diabetes, dy [....] » Read More
Introduction: Atrial fibrillation (AF) is one of the most common and probable serious arrhythmia and a hallmark of an increasing risk of pathological thrombus formation. Interestingly, normal sinus rhythm (NSR) is the standard rhythm in a normal person. The sino-atrial node (SAN) [....] » Read More
Title : The development of human relaxin-2 for heart failure with preserved ejection fraction, HFpEF
Thomas Bernd Dschietzig, Relaxera GmbH & Co. KG, Germany
Human relaxin-2 (hRlx-2) is a hormone of pregnancy that has engendered a great deal of interest as a therapy for various cardiovascular and inflammatory diseases, among them Acute Heart Failure and Systemic Scleroderma. Here, we propose and summarize data showing that Rlx-2 repre [....] » Read More
Title : Pulse field ablation for atrial fibrillation complications: What do we know yet
Narendra Kumar, HeartbeatsZ Academy, United Kingdom
Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting millions worldwide. While catheter ablation is a well-established treatment for AF, it carries risks of complications such as pulmonary vein stenosis (PVS) and esophageal injury. Pulse field ablation (PF [....] » Read More
Title : Clinical pharmacology of sotatercept - The novel quality advancement in biological therapy of pulmonary arterial hypertension
Miroslav Radenkovic, University of Belgrade, Serbia
Pulmonary arterial hypertension (PAH) remains a debilitating disease with high morbidity and mortality. It is a rare, progressive and ultimately life-threatening disease in which blood vessels in the lungs thicken and narrow, causing significant strain on the heart. Patients with [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through bio design-driven translational applications and cardiology-related marketing to secure the human healthcare and biosafety
Sergey Suchkov, The Russian University of Medicine, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogni [....] » Read More
Title : Cardiovascular nanomedicine: Stopping strokes, unclogging arteries, and restoring heart function
Thomas J Webster, Hebei University of Technology, China
Nanomedicine, or the use of materials with at least one dimension less than 100 nm, has led to improved disease prevention, diagnosis, and treatment. This talk will cover recent advances in the use of nanomaterials to prevent, diagnose, and treat cardiovascular diseases. Specific [....] » Read More
Title : Harnessing heart health: Unveiling the dual benefits of SGLT2 inhibitors in rat hearts
Desislava Doycheva, Loma Linda University, United States
Cardiovascular diseases, particularly myocardial infarction (MI), remain a major global health challenge. Recent studies have highlighted the cardioprotective potential of sodium-glucose co-transporter 2 (SGLT2) inhibitors, originally developed for managing glycemia in diabetes. [....] » Read More
Title : Reliable cuffless blood pressure monitoring using multiple artificial intelligence models
Prabode Weebadde, Purdue University, United States
Cardiovascular disease (CVD) remains the leading cause of death globally, with a life lost every three seconds in the U.S. Early detection and effective hypertension management are crucial to reducing its impact. However, traditional cuff-based blood pressure (BP) monitors, while [....] » Read More
Title : The hidden gem of the aortic valve
Angela Maria Torres Torres, Marshall University, United States
Background: Quadricuspid aortic valve is a rare congenital cardiac defect with estimated incidence rate of 0.013%. Historically, encountered during open heart surgery or postmortem. Currently diagnosed primarily via transechocardiography. The etiology hypothesis involves the part [....] » Read More
Title : Heart-to-Heart: Transforming cardiac care through communication
Iris Panagiota Efthymiou, University of Greenwich, United Kingdom
Effective communication is at the heart of quality patient care, especially in cardiology, where complex medical decisions can significantly impact patient outcomes. This speech addresses the critical role of communication between cardiologists and patients in enhancing cardiac c [....] » Read More
Title : Functional characterization of KCNH2 genetic variants, encoding HERG potassium channel, as a clinically-relevant information for type 2 LQTS syndrome
Barbara Ribeiro de Oliveira Mendes, INSERM, France
Long QT syndrome type 2 (LQTS2) is a potentially fatal cardiac arrhythmia disorder, often resulting from rare loss-of-function variations in the KCNH2 gene, encoding the hERG cardiac channel. The identification of hERG variants is essential for diagnosing LQTS2 and providing appr [....] » Read More
Title : Antibodies with functionality as a new generation of translational tools designed to monitor autoimmune myocarditis at clinical and subclinical stages
Sergey Suchkov, The Russian University of Medicine, Russian Federation
Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs) with a capacity to hydrolyze the antigenic (Ag) substrate. In this sense, proteolytic Abs (Ab-proteases) represent Abs to provide proteolytic effects. Abs against Cardiac Myosin (CM) with proteolytic activity exhibiting [....] » Read More
Title : A rare case of slow flow mimicking acute coronary syndrome
Nidhish Niranjan Nisty, Nisty Heart Centre, India
Introduction: The coronary slow flow phenomenon is an important, angiographic entity characterized by delayed progression of the injected contrast medium through the coronary tree. The clinical implications are significant, with over 80% of patients experiencing recurrent chest p [....] » Read More
Title : Pacemaker pocket infection management in resource limited setting
Shibikom Tamirat, Childrens’ Heart Fund of Ethiopia, Ethiopia
With the advent of interventional cardiology service in Ethiopia, there is increasing number of pacemaker pocket infection. In principle, pacemaker pocket infection shoud be managed with explantation of the generator and the leads as well. Then the patient will be kept on tempora [....] » Read More
Title : The effects of local heat therapy on chest pain in patients with acute coronary syndrome
Ali Mohammadpour, Gonabad University of Medical Sciences, Iran (Islamic Republic of)
Introduction: Chest pain is a common complaint in patients with acute coronary syndrome(ACS). Pharmacological pain management is associated with different side effects. This study aimed to determine the effect of local heat therapy on the chest pain in patients with ACS. [....] » Read More
Title : The impact of gender on prognosis in hospitalised patients with heart failure and reduced ejection fraction
Hattab Oumayma, Centre Hospitalier Universitaire Mohammed VI, Morocco
Introduction: It is a well-knowned that important differences in heart failure patient with reduced ejection fraction (HFrEF) exist between men and women. However, the impact of gender on mortality in this category of patients has not been sufficiently studied. Purpose:&n [....] » Read More
Title : The long-term effects of structured lifestyle interventions on the absolute 10-year cardiovascular disease risk among Asian Indians: Results from the follow-up study of the Kerala diabetes prevention program
Getu Debalkie Demissie, Baker Heart and Diabetes Institute and La Trobe University, Australia
Background: Studies have demonstrated the short-term effectiveness of structured lifestyle interventions in lowering absolute cardiovascular disease (CVD) risk among individuals at high risk for type 2 diabetes. However, their long-term impact remains unclear. Objective: This [....] » Read More
Title : New sternal retractor for harvesting of bilateral internal thoracic arteries
Yoandy Lopez de la Cruz, Ministry of Public Health, Cuba
Internal thoracic artery (ITA) harvesting is an important surgical procedure in cardiovascular surgery. In recent decades, more and more patients are revascularized with grafts from both internal thoracic arteries, which has shown better long-term outcomes. Since Favaloro introdu [....] » Read More