Title : Coronary vessel formation in development and regeneration: Origins and mechanisms
Abstract:
Neovascularization of the ischemic myocardium following infarction is vital for the survival of cardiomyocytes and prevention of heart failure. However, the intrinsic revascularization following ischemic injury in the heart is inadequate to restore blood flow to the infarcted myocardium. A comprehensive understanding of how coronary vasculature is constructed and what developmental pathways might be reactivated after infarction is beneficial to develop effective strategies for heart revascularization. The latest lineage tracing studies of coronary vasculature have revealed multiple developmental origins for coronary vascular endothelial cells. The development and growth of coronary vessels emanated from different cellular origins are governed by distinct regulatory mechanisms. Here, we highlight recent research advancements on cellular sources and molecular mechanisms of coronary vessel formation during heart development and regeneration, and also elaborate on how these mechanisms can be reactivated or recapitulated to facilitate therapeutic revascularization in ischemic heart disease.
Audience Take Away
- Explain how the audience will be able to use what they learn?
The audience will be able to use the knowledge of coronary vessel formation they learned to study coronary regeneration and cardiovascular disease. - How will this help the audience in their job?
Some research methods will help the audience to study how to regenerate coronary vessels following cardiac injury. - Is this research that other faculty could use to expand their research or teaching?
Of course. They could use to expand their research or teaching.
