Title : Surgical fetal stem cells implantation in heart failure patients long term results at 14 years
Abstract:
Direct myocardial transplantation of HFDSCs (Fetal Liver Stem Cells) by open-chest surgical procedure was performed in 10 patients with HF due to nonischemic, nonchagasic dilated cardiomyopathy. All 10 patients survived the operation. At 40 months, the mean (+/-SD) NYHA class decreased from 3.4 +/- 0.5 to 1.33 +/- 0.5 (P=0.001); the mean EF increased 31%, from 26.6% +/- 4% to 34.8% +/- 7.2% (P =0.005); and the mean ETT increased 291.3%, from 4.25 minutes to 16.63 minutes (128.9% increase in metabolic equivalents, from 2.46 to 5.63) (P<0.0001); the mean LVEDD decreased 15%, from 6.85 +/- 0.6 cm to 5.80 +/- 0.58 cm (P<0.001); mean performance in the 6-minute walk test increased by 43.2%, from 251 +/- 113.1 seconds to 360 +/- 0 seconds (P =0.01); the mean distance increased 64.4%, from 284.4 +/- 144.9 m to 468.2 +/- 89.8 m (P =0.004); and the mean result in the Minnesota test decreased from 71 +/- 27.3 to 6 +/- 5.9 (P<0.001) 6 patients survived after 40 months 5 of these had complete reverse remodeling after 3 months of implantation.
Results: One patient at 3,6 years that doesn’t have complete reverse remodeling of the left ventricle died of arritmia the second patient died at 5,4 years for an infection the third patient died at 5,10 years without know the cause (Infection?) the fourth patient died at 7,4 years of heart failure, the fifth patient died at 8,4 years of heart failure, the six patient died at 14,4 years at 83 years old for heart failure.
Conclusion: These Initial World wide experience with the surgical direct implantation off liver fetal stem cells in patients with Terminal Heart Failure shows clearly the positive effect in the reverse remodeling of the left ventricle of 50% of the patients and excellent long term results in these type of patients and opens a new avenue for the treatment of the patients of Terminal Heart Disease without any option of treatment.
