Direct myocardial transplantation of HFDSCs (Fetal Liver Stem Cells) by open-chest surgical procedure was performed in 10 patients with HF due to nonischemic, nonchagasic dilated cardiomyopathy. All 10 patients survived the operation. At 40 months, the mean (+/-SD) NYHA class dec [....] » Read More
Oncological diseases are the second most common cause of death among adults worldwide after cardiovascular diseases (CVD). In clinical practice, comorbidity of cancers and CVD is increasingly registered, which certainly increases the risk of death. The main cause of death in pati [....] » Read More
Lipoprotein (a) [Lp(a)] is a unique lipoprotein particle composed of an LDL-like particle linked to a glycoprotein called apolipoprotein(a). Elevated levels of Lp(a) have been identified as an independent risk factor for cardiovascular disease, including atherosclerosis, heart at [....] » Read More
The APN functions as the patient advocate, the care facilitator and the optimizer of the patient’s hospital journey and experience. Areas of practice: Advanced knowledge and experience in the management of implanted cardiac devices, optimizing their function, enabl [....] » Read More
Background: Direct-acting oral anticoagulants (DOACs) are absorbed in the upper gastrointestinal tract, but patients with gastrointestinal disease were not included in the Phase II and III drug investigations. This report details a patient with altered gastrointestinal anatomy an [....] » Read More
Kinetic modeling is an essential method in understanding the dynamic interactions of biological systems, particularly in the context of cardiovascular physiology. This study delves into the application of kinetic modeling to elucidate the heart's function as a critical input [....] » Read More
Although the regulation of cholesterol homeostasis in the body has been extensively studied, there is little information on how this regulation takes place in the brain. Cholesterol does not cross the blood-brain barrier; therefore cholesterol metabolism in the brain is independe [....] » Read More
Introduction: Diseases such as acute coronary syndromes (ACS), with signs such as difficulty breathing when exerting effort or chest pain at rest, are frequently expressed in patients with coronary artery diseases (CAD). The percentage of patients with myocardial ischemia without [....] » Read More
Chronic pain is defined as persistent pain for more than three months and can be classified as primary with no known etiology, or secondary pertinent to a pathological process and specific clinical diagnosis. In previous studies, we observed that it directly impacts cardiac rehab [....] » Read More
Composite textile stents with core-shell structure have been developed. Biodegradable polyvinyl alcohol (PVA) yarns are twisted and then coated with polycaprolactone/polyethylene glycol (PEG) blends. The coated yarns are weft knitted into braids and then thermally treated to form [....] » Read More
Background: Coronary artery disease (CAD) results from the obstruction of blood supply to the heart. Angioplasty is a common intervention for managing CAD, supplemented by supportive and preventive therapies. Modifiable risk factors for CAD include hypertension, diabetes, dy [....] » Read More
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Modern pharmacology offers a variety of treatments, yet the rising prevalence of CVDs necessitates alternative and complementary strategies. Nature, with its vast repository of medicinal pl [....] » Read More
Introduction: Atrial fibrillation (AF) is one of the most common and probable serious arrhythmia and a hallmark of an increasing risk of pathological thrombus formation. Interestingly, normal sinus rhythm (NSR) is the standard rhythm in a normal person. The sino-atrial node (SAN) [....] » Read More
Patent Foramen Ovale (PFO) is a common anatomical lesion occurring in 20-34% of the population, and it may be a cause for paradoxical embolism to the cerebral or coronary arteries causing stroke or myocardial ischemia. PFO management in patients with thrombophilia without prior c [....] » Read More
Streptococcus agalactiae, commonly known as Group B strep (GBS), is an uncommon pathogen in most adults and is typically only seen in pregnant women and neonates. Local and systemic complications from GBS typically have a high mortality rate, with infective endocarditis (IE) bein [....] » Read More
Objective: Aortic dissection is closely associated with inflammation. Currently, red blood cell distribution width (RDW) has been regarded as a novel inflammatory biomarker. The role of RDW on the prognosis of patients with Type A aortic dissection after surgery still remains unc [....] » Read More
Objective: Coronary artery bypass grafting (CABG) via sternotomy is the standard and conventional procedure for patients with multivessel coronary artery disease. Minimally invasive coronary artery bypass grafting (MICS CABG) via left thoracotomy has become an alternative procedu [....] » Read More
Title : Exploring new biomarkers of cardiomyopathy
Shuping Zhong, University of Southern California, United States
Myocardial hypertrophy manifests magnification of cardiomyocyte volume rather than number increasing in the adult heart. The differentiation of cardiomyocytes shortly terminates after birth. The cardiomyocytes no longer proliferate like other tissue cells. Myocardial hypertrophy [....] » Read More
Title : The development of human relaxin-2 for heart failure with preserved ejection fraction, HFpEF
Thomas Bernd Dschietzig, Relaxera GmbH & Co. KG, Germany
Human relaxin-2 (hRlx-2) is a hormone of pregnancy that has engendered a great deal of interest as a therapy for various cardiovascular and inflammatory diseases, among them Acute Heart Failure and Systemic Scleroderma. Here, we propose and summarize data showing that Rlx-2 repre [....] » Read More
Title : Pulse field ablation for atrial fibrillation complications: What do we know yet
Narendra Kumar, HeartbeatsZ Academy, United Kingdom
Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting millions worldwide. While catheter ablation is a well-established treatment for AF, it carries risks of complications such as pulmonary vein stenosis (PVS) and esophageal injury. Pulse field ablation (PF [....] » Read More
Title : Clinical pharmacology of sotatercept - The novel quality advancement in biological therapy of pulmonary arterial hypertension
Miroslav Radenkovic, University of Belgrade, Serbia
Pulmonary arterial hypertension (PAH) remains a debilitating disease with high morbidity and mortality. It is a rare, progressive and ultimately life-threatening disease in which blood vessels in the lungs thicken and narrow, causing significant strain on the heart. Patients with [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through bio design-driven translational applications and cardiology-related marketing to secure the human healthcare and biosafety
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogni [....] » Read More
Title : Cardiovascular nanomedicine: Stopping strokes, unclogging arteries, and restoring heart function
Thomas J Webster, Hebei University of Technology, China
Nanomedicine, or the use of materials with at least one dimension less than 100 nm, has led to improved disease prevention, diagnosis, and treatment. This talk will cover recent advances in the use of nanomaterials to prevent, diagnose, and treat cardiovascular diseases. Specific [....] » Read More
Title : 5 Tools for physician wellness: The link is what you think
Michael R Mantell, University of Pennsylvania, United States
Physicians are increasingly faced with the dual burden of delivering exceptional care while navigating the pressures of high-stakes environments. These challenges, compounded by long hours, emotional demands, and administrative responsibilities, have led to a crisis in physician [....] » Read More
Title : Harnessing heart health: Unveiling the dual benefits of SGLT2 inhibitors in rat hearts
Desislava Doycheva, Loma Linda University, United States
Cardiovascular diseases, particularly myocardial infarction (MI), remain a major global health challenge. Recent studies have highlighted the cardioprotective potential of sodium-glucose co-transporter 2 (SGLT2) inhibitors, originally developed for managing glycemia in diabetes. [....] » Read More
Title : Biomechanical evaluation of sternal closure stability with and without demineralized bone matrix graft: An FEA study
Ravi Kanagala, LCMC Health, United States
The use of biologics in sternal closures is underexplored, previous studies suggest biologic augmentation can enhance patient outcomes. This study evaluated the biomechanical performance of two sternal closure techniques; stainless steel wire and titanium plate fixation under var [....] » Read More
Title : The hidden gem of the aortic valve
Angela Maria Torres Torres, Marshall University, United States
Background: Quadricuspid aortic valve is a rare congenital cardiac defect with estimated incidence rate of 0.013%. Historically, encountered during open heart surgery or postmortem. Currently diagnosed primarily via transechocardiography. The etiology hypothesis involves the part [....] » Read More
Title : Wearables and Activity
Praveen Veerabhadrappa, Penn State University, United States
Introduction/Purpose: Activity trackers monitor activity and health which can track progress in activity within the chronic disease population. The purpose of this study was to validate the step counts of Apple Watch and compare wrist-, hip- and ankle- worn Actigraphs during over [....] » Read More
Title : Heart-to-Heart: Transforming cardiac care through communication
Iris Panagiota Efthymiou, University of Greenwich, United Kingdom
Effective communication is at the heart of quality patient care, especially in cardiology, where complex medical decisions can significantly impact patient outcomes. This speech addresses the critical role of communication between cardiologists and patients in enhancing cardiac c [....] » Read More
Title : A decade of DCD heart transplantation utilising normothermic machine perfusion in Australia
Claudio Soto, St Vincent's Hospital, Australia
The use of donation after circulatory death (DCD) donors for heart transplantation represents a relatively new entry into efforts made to help expand the donor pool. The use of Normothermic Machine Perfusion (NMP) through the Transmedics Organ Care System Heart (OCS Heart) allows [....] » Read More
Title : I felt really unsupported: How the health care system can better engage with informal caregivers of people with heart failure
Katherine Carleton Eagleton, University of Canberra, Australia
In Australia, the self-management of heart failure in the patient’s home is recommended by Clinical Guidelines to decrease (re)hospitalisation and mortality and should actively include both the patient and their caregiver. However, there is an expectation that as part of th [....] » Read More
Title : Smoking status and early vascular aging: How to reduce cardiovascular risk at the current stage of knowledge?
Alexander Filippov, St. Petersburg State University, Russian Federation
Background: Smoking status (SS) is associated with structural and functional vascular changes which may lead to increased arterial stiffness and, as a consequence, the formation of early vascular aging. The purpose of this study was to investigate the relationship between th [....] » Read More
Title : Antibodies with functionality as a new generation of translational tools designed to monitor autoimmune myocarditis at clinical and subclinical stages
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs) with a capacity to hydrolyze the antigenic (Ag) substrate. In this sense, proteolytic Abs (Ab-proteases) represent Abs to provide proteolytic effects. Abs against Cardiac Myosin (CM) with proteolytic activity exhibiting [....] » Read More
Title : Automated assessment of atrial septal defects using deep learning
Zhang Xin, Capital Medical University, China
Aim: Atrial septal defect (ASD) is a typical cardiac defect in the atrial septum, which accounts for around 10% of congenital heart disease (CHD). The early diagnosis and treatment of ASD are crucial to avoid serious complications. Conventional pre-treatment assessment methods to [....] » Read More
Title : Double-chambered left ventricle - From clinical to basic
Fangyun Wang, Capital Medical University, China
Introduction: Double-chambered left ventricle (DCLV) is a particularly rare congenital cardiovascular malformation that is difficult to diagnose. It is characterized by the subdivision of the left ventricle into two chambers by an abnormal septum or muscle band. Compared to [....] » Read More
Title : Diagnosis and prognosis of abnromal origin of coronary arteries
Ma Ning, Capital Medical University, China
Objective: To investigate the diagnostic and prognostic value of echocardiography in patients with anomalous origin of the coronary arteries(AOCA),and to analyze its diagnostic accuracy and impact on patient outcomes. Methods: A retrospective analysis was conducted on clinical [....] » Read More
Title : A rare case of slow flow mimicking acute coronary syndrome
Nidhish Niranjan Nisty, Nisty Heart Centre, India
Introduction: The coronary slow flow phenomenon is an important, angiographic entity characterized by delayed progression of the injected contrast medium through the coronary tree. The clinical implications are significant, with over 80% of patients experiencing recurrent chest p [....] » Read More
Title : 7 stepwise approach in ECG interpretation using cardiac vector theory
T Rajini Samuel, Shri Sathya Sai Medical College and Research Institute, India
Introduction: Electrocardiogram (ECG) interpretation plays an immense clinical role for the diagnosis of coronary heart disease. But its interpretation remains a challenging task for junior medical staffs. Einthoven applied vectors to discuss the cardiac electrical activity even [....] » Read More
Title : Comparison of autologous vs non-autologous blood transfusion in patients undergoing coronary artery bypass grafting surgery
Muhammad Wasim Sajjad, Rehman Medical Institute, Pakistan
Introduction: To compare autologous versus non-autologous transfusion in patients undergoing CABG and its early outcomes. This study seeks to evaluate the impact of different transfusion strategies on key postoperative outcomes, including morbidity and mortality. Methodology: [....] » Read More
Title : Tumor-like calcification in patients undergoing hemodialysis
Omaima Taie, Mohammed V University, Morocco
Tumor-like calcinosis is a condition where calcium phosphate crystals accumulate in the tissues around joints, forming large, calcified masses. Although the exact mechanisms are not fully understood, it is believed that an elevated calcium-phosphate product and severe hyperparath [....] » Read More
Title : Peripheral artery disease: A hidden threat to heart function
Omaima Taie, Mohammed V University, Morocco
Background: Peripheral artery disease (PAD) is often linked to heart failure with preserved ejection fraction (HFpEF), a condition characterized by impaired left ventricular (LV) relaxation during diastole. LV diastolic dysfunction is a critical component of HFpEF. This investiga [....] » Read More
Title : The effects of local heat therapy on chest pain in patients with acute coronary syndrome
Ali Mohammadpour, Gonabad University of Medical Sciences, Iran (Islamic Republic of)
Introduction: Chest pain is a common complaint in patients with acute coronary syndrome(ACS). Pharmacological pain management is associated with different side effects. This study aimed to determine the effect of local heat therapy on the chest pain in patients with ACS. [....] » Read More
Title : Pacemaker pocket infection management in resource limited setting
Shibikom Tamirat, Childrens’ Heart Fund of Ethiopia, Ethiopia
With the advent of interventional cardiology service in Ethiopia, there is increasing number of pacemaker pocket infection. In principle, pacemaker pocket infection shoud be managed with explantation of the generator and the leads as well. Then the patient will be kept on tempora [....] » Read More
Title : Risk prediction and quantification of cardiovascular disease using machine learning: Advancing early diagnosis with clinical insights
Vijay Suryakant Kapse, Kasturba Medical College, India
Cardiovascular diseases (CVDs) account for nearly 18 million deaths annually, placing a significant burden on global healthcare systems, particularly in underrepresented regions. Early risk prediction remains critical for timely interventions and improved patient outcomes. This s [....] » Read More
Title : Investigating CRISPR-Cas9-mediated knock-in for PECAM-1 reporter line generation in HEK293T cells
Ali Hassan, King's College London, United Kingdom
Introduction: Platelet Endothelial Cell Adhesion Molecule (PECAM-1) is a transmembrane glycoprotein crucial for vascular endothelial cell (VEC) differentiation from precursor cells. Monitoring PECAM-1 expression within human induced pluripotent stem cell (hiPSC) models is essenti [....] » Read More
Title : The long-term effects of structured lifestyle interventions on the absolute 10-year cardiovascular disease risk among Asian Indians: Results from the follow-up study of the Kerala diabetes prevention program
Getu Debalkie Demissie, Baker Heart and Diabetes Institute and La Trobe University, Australia
Background: Studies have demonstrated the short-term effectiveness of structured lifestyle interventions in lowering absolute cardiovascular disease (CVD) risk among individuals at high risk for type 2 diabetes. However, their long-term impact remains unclear. Objective: This [....] » Read More
Title : The association between visit-to-visit variability in established risk factors and incident CVD: A post-hoc analysis of the multi-ethnic study of atherosclerosis
Abderrahim Oulhaj, Khalifa University, United Arab Emirates
Background: There has been a growing interest in investigating the association between visit-to-visit variability in established risk factors and the incidence of cardiovascular disease (CVD). Some research has demonstrated that larger within-patient variability in certain e [....] » Read More
Title : New sternal retractor for harvesting of bilateral internal thoracic arteries
Yoandy Lopez de la Cruz, Ministry of Public Health, Cuba
Internal thoracic artery (ITA) harvesting is an important surgical procedure in cardiovascular surgery. In recent decades, more and more patients are revascularized with grafts from both internal thoracic arteries, which has shown better long-term outcomes. Since Favaloro introdu [....] » Read More
Title : Diagnostic odyssey of microvascular abnormalities in INOCA: 13N-ammonia and gadolinium synchronous dual-perfusion PET/MR approach
Runze Wen, The First Affiliated Hospital of USTC, China
Background: Ischemia with no obstructive coronary arteries (INOCA), a chronic disorder with a poor prognosis, remains diagnostically challenging. Positron emission tomography (PET) has been established as the non-invasive reference benchmark for quantifying myocardial blood flow [....] » Read More
Title : Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress
Hua Wan, Nanjing Medical University, China
In humans, ACTN2 mutations are identified as highly relevant to a range of cardiomyopathies such as DCM and HCM, while their association with sudden cardiac death has been observed in forensic cases. Although ACTN2 has been shown to regulate sarcomere Z-disc organization, a causa [....] » Read More
Title : Paravetebral block with liposomal bupivacaine for enhanced recovery in open thoracotomy : A case report
Vivek Vaibhav, Rama Medical college Hospital and Research Center, India
A 77-year-old Female patient underwent an open thoracotomy for lung B/L breast cancer. Preoperative PVB was performed at the T5-T7 levels, using a combination of liposomal bupivacaine and standard bupivacaine for both intraoperative anesthesia and postoperative pain relief. [....] » Read More
Title : Iron deficiency in chronic heart failure patients at the University Teaching Hospital in Lusaka, Zambia
Sandra Lungu, Lusaka Apex Medical University, Zambia
Iron plays a key role in oxygen uptake, transport, storage, and oxidative metabolism in the muscle including myocardium. Iron deficiency (ID) in chronic heart failure (CHF) patients has a mortality of 35% is reported at the university teaching hospital (UTH). Information on ID in [....] » Read More
Title : Constrictive pericarditis following lung transplantation: A rare cardiovascular complication in idiopathic pulmonary fibrosis
Abdul Rahman Elhassan, National University, Sudan
Constrictive pericarditis is an uncommon but serious complication of lung transplantation, marked by pericardial fibrosis and impaired diastolic filling. It can lead to significant morbidity if not recognized and treated early. This case highlights a rare instance of constrictive [....] » Read More