Title : Residual cardiovascular risk indices I and II in type II diabetics and hypertensive patients
Abstract:
Introduction: Diseases such as acute coronary syndromes (ACS), with signs such as difficulty breathing when exerting effort or chest pain at rest, are frequently expressed in patients with coronary artery diseases (CAD). The percentage of patients with myocardial ischemia without flow-limiting epicardial stenosis varies from <20% luminal stenosis to ≤50%, or even absence of severe >70% stenosis in any coronary artery. The objective of this work is to evaluate two indices of residual cardiovascular risk I and II (RCVR I and II) with risk of coronary obstruction in asymptomatic patients by measuring laboratory analytes associated with inflammatory vascular processes.
Methods: A descriptive, randomized, retrospective and observational study was carried out in a sample of patients of both sexes who attended consultation at the Reina Fabiola university clinic, Córdoba, Argentina during the period 2015-2017. The variables analyzed were the cardiac markers cTnI, systolic blood pressure (SBP), heart rate (HR), age, body mass index (BMI), blood glucose (mg%), % glycosylated hemoglobin (%HbA1c). With these analytes, the residual cardiovascular risk indices I and II (RCVR I and II) were constructed.
Results: Regarding RCVR I, it was observed that control patients have a negative mean -0.556 ± 0.16, which according to their interpretation is not at risk of suffering from atherogenic lesions; opposite aspect to that observed in diabetic patients (0.345 ± 2.03) and hypertensive patients (0.306 ± 2.10). In the case of hypertensive patients, when contrasted with controls referred to RCVR I, patient 3 (-2.71) has a better prognosis than number 6 (5.62). Slight positive linear correlation test was found in hypertensive patients between RCVR I and cTnI values ??(r: 0.5723) p = 0.0054, and negative correlation between RCVR II and cTnI (r: -0 .7239) p = 0.0001.
Conclusion: The incorporation, analysis and evaluation of biochemical parameters such as blood glucose, cTnI, HbA1c together with clinical values ??such as blood pressure, body mass index are important for the assessment of the greater or lesser residual cardiovascular risk and consequently the probability of developing vascular lesions among them. coronary arteries early in asymptomatic patients.
