Effect of arjunolic acid as potential therapeutic constituent in experimental myocardial infarction

Title : Effect of arjunolic acid as potential therapeutic constituent in experimental myocardial infarction

Abstract:

Myocardial infarction is common manifestations of cardiovascular disease. Our aim was to investigate the protective effect of Arjunolic acid and elucidate its underlying mechanisms on isoproterenol induced myocardial infarction in rats. Arjunolicacid (300 mg/kg) was administered to rats orally for 30 days. Isoproterenol (120 mg/kg) was injected subcutaneously at an interval of 24 hours twice to induce myocardial infarction. Myocardial infarction was confirmed by the abnormal increased activities of serum cardiac enzymes and cardiac tissue malondialdehyde, while a significant decrease in serum level of antioxidant defense system and nitrite with altered lipid pro?le in the serum and heart as compared to the normal control group. Pretreatment with Arjunolicacid followed by isoproterenol injection significantly prevented almost all the parameters of isoproterenol induced myocardial infarction. Results were con?rmed by the histopathological examination. Arjunolic acid pretreatmentup regulated the expression of endothelial nitric oxide synthase, whereas expressions of nuclear factor-kappa B and tumor necrosis factor-alpha were downregulated in isoproterenol-treated rats. This suggests that the protective effects of Arjunolic acid   may be mediated through up regulation of nitric oxide production, increased antioxidant mechanisms, and its ability to inhibit tumor necrosis factor-alpha  and nuclear factor-kappa B activation.

Keywords: Myocardial Infarction, Arjunolic Acid, Tumor Necrosis Factor-Alpha, Nuclear Factor-Kappa B, Antioxidants.

Biography:

Dr. Souravh Bais, Working as Associate Professor in Pharmacology, SAGE University, Institute of Pharma. Sci. Sagar, India. He has more than 13 years of experience in teaching and research. He has published more than 60 papers in peer reviewed journals in both national and international journals. His areas of research are neurological disorders, Obesity and inflammatory disorders. Some of his research papers are highly appreciated in scientific community which is published in “Biomedicine and Pharmacotherapy” (SCI Journal) and CNS & Neurological Disorders - Drug Targets (SCI Journal). His paper was awarded as best research paper award in various international conferences.He is acting as Academic Reviewer in Science Domain and Invited as reviewer for articles- Elsevier, Springer. He is awarded as “certificate of outstanding contribution in Reviewing “on Sept. 2018 by Biomedicine and Pharmacotherapy (SCI Journal).  He is awarded as “Young Achiever Award 2019” by Institute of Scholars Bengaluru-560091, Karnataka, India. He is a member of American Society of Pharmacology and Experimental Therapeutics (ASPET). He is selected as “Bentham Ambassador” for the year 2019-20. Recently he received an international travel grant from ICMR to present his research in ICBEB 2019, South Korea.