Fibrinolytic therapy, also known as thrombolytic therapy, is a medical intervention aimed at dissolving blood clots within the circulatory system. Blood clots, or thrombi, can pose significant health risks when they obstruct blood vessels, leading to conditions such as myocardial infarction (heart attack) or ischemic stroke. Fibrinolytic agents, such as tissue plasminogen activator (tPA), work by promoting the breakdown of fibrin, a protein that plays a crucial role in blood clot formation. Administration of fibrinolytic therapy is often time-sensitive, particularly in the case of acute conditions like heart attacks, where rapid intervention can prevent or minimize tissue damage. Despite its efficacy, fibrinolytic therapy carries certain risks, including the potential for bleeding complications. Therefore, its use is carefully considered based on individual patient factors and the specific clinical scenario. As medical science continues to advance, researchers explore refined approaches to enhance the safety and effectiveness of fibrinolytic therapy, contributing to the ongoing evolution of cardiovascular and cerebrovascular care.
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Ahdy Wadie Helmy, Indiana University School of Medicine, United States
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Thomas J Webster, Hebei University of Technology, China
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