Title : Personalized and Precision Medicine (PPM) and PPN-guided cardiology practice as a unique model via translational applications and upgraded business modeling to secure human healthcare, wellness and biosafety
Abstract:
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). The pace of inno-vation in Personalized & Precision Cardiology (PPC) is thus becoming fast including:
- The success of transcatheter aortic valve implantation for patients or per-sons-at-risk at lower levels of surgical risk, or procedures to ablate atrial fibrillation with high degrees of success, and other interventional procedures.
- Global shift from treating disease and preventing the secondary recurrence of cardiovascular events to the primary and even primordial prevention of cardio-vascular risk and the promotion of cardiovascular health.
- The widespread advent of wearable and implantable technologies, allowing con-tinuous monitoring of cardiovascular parameters.
- Nanotechnology and microfluidics, AI and related areas to become the most rap-idly emerging areas of cardiovascular research and the most promising technolo-gies for improving health care and health outcomes.
A major paradigm shift has become the increasing recognition of the potential therapeutic utility of the targeted drugs for cardiovascular diseases, whilst opening up new avenues of therapeutic implications. As PPM continues to drive targeted immunotherapy development and cardiac biomarker discovery for healthcare services, cardiologists could indeed see their own PPM-based renaissance very soon. The above-mentioned areas being an integral part of PPM-related cardiac research is really an interdisciplinary field that results from the application of the innovative tools to medicine and has the potential to significantly improve some canonical treatments, prevention, prophylaxis and rehabilitation. Specifically, in the field of PPC, we expect to have a great im-pact in the near future due to its multiple ad-vantages, namely its versatility to adapt a drug to cohorts of patients and/or persons-at-risk.
PPM and PPC are thus poised to become the next great revolution in the daily practice, as well as in the maintenance of cardiovascular health and the prevention and cure of cardio-vascular disease. PPM disrupts standard practice and draws from clinical testing, electronic health records, pan-omics profiling, big datasets, and novel analytical methods, to create a person-specific phenotype to identify an optimal intervention with minimal risk. The promise of PPM and PPC is well understood but the newest tools will be needed for de-scribing the cardiovascular health status of individuals and populations, including 'omics' data, exposomics and social determinants of health, behaviours and motivations, patient-generated data, and the array of data in EMRs. Cardiology and cardiac micro- and nanosur-gery currently lead the way in PPC advancements, and health care under PPM-related ar-mamentarium will become a more integrated, dynamic system, in which patients are no longer a passive entity on whom measurements are made, but instead are central stake-holders who contribute data and participate actively in shared decision-making.
Encompassing functional cardiology, integrative medicine, and metabolic medi-cine/cardiology, we would suggest an up-to-date, expert approach to heart health wellness and treating the diseased heart and blood vessels. The proposal would ideally be suited for practitioners who already incorporate integrative approaches in their practice, as well as more traditional clinicians who want to learn more about PPM and PPC as a growing area. PPM will need to demonstrate that phenotype-based person-specific interventions are supe-rior to the current standard of care and, ultimately, have a population effect by moving the mean on the disease spectrum towards Health. This is the reason for developing global sci-entific, clinical, social, and educational projects in the area of PPM to elicit the content of the new branch. In short, PPM will transform the way the physicians practice and will shake up the entire pharmaceutical value chain.
