Many systemic diseases, such as diabetes, chronic kidney disease, and autoimmune disorders, often contribute to significant cardiovascular complications. These complications arise due to the interconnected nature of the body’s systems, where conditions like uncontrolled diabetes accelerate atherosclerosis or chronic inflammation from autoimmune diseases increases the risk of heart failure. Cardiovascular complications in other diseases can manifest as hypertension, coronary artery disease, or arrhythmias, complicating the management of the primary condition. Addressing these issues requires a multidisciplinary approach that combines cardiology with other specialties to optimize patient outcomes, emphasizing early detection, lifestyle interventions, and targeted therapies to mitigate risks and improve quality of life.