Title : The study of cardiac troponin I in ST segment elevation myocardial infarction and its complications
BACKGROUND AND OBJECTIVE
A flawless and prompt approach is required to manage patients with STEMI and its course especially its complications. Many studies earlier have suggested cardiac troponins like troponin I levels are elevated in STEMI and are directly proportional to prognosis of course of the disease. Present study was performed to study the prognostic and diagnostic significance of cardiac troponin I in ST elevation and its complications. It was also to study the quantitative corelation of cardiac troponin I with ST elevation MI and its complications.
Fifty cases were studied from November 2018 to May 2020. Cases diagnosed to have of ST elevation MI as per AHA/ESC/ACC guidelines within 6 hours onset of symptoms. All the patients were examined and investigated according the proforma. They received treatment as per AHA/ESC/ACC guidelines. During hospital stay, they were observed for predefined complications.
Among the fifty cases, mean age ? SD in the study group was 53.76±11.03 years and ranged from 22 to 70 years. Male patients 36(72%) outnumbered the female patients 14 (28%) and Male: Female ratio is 2.51:1. Most common symptom was chest pain (100%) followed by sweating (34%) and pain radiating to arm (34%).
Major risk factors were cigarette smoking (62%), Diabetes Mellitus (42%), hypertension (32%). AWMI was more common with 70% of patients and 30% were IWMI. Tenecteplase 30mg was most used as thrombolytic agent administered to 70% of patients. In these patients 92% of them had elevated Cardiac Troponin-I levels and 8% had normal Troponin –I levels. Among these with elevated Troponin-I levels 44% of the patients experienced complications. Most common complications being arrhythmia 45.46% and next being the heart failure 40.9%. Mortality in the study is 6%.
INTERPRETATION AND CONCLUSION
Cardiac Troponin-I is a reliable diagnostic as well as prognostic indicator in patients with STEMI.
The magnitude of Cardiac Troponin-I levels is directly proportional to myocardial damage and adverse course of STEMI including its complications and mortality.
Take home message
- Audience can learn about Troponin I diagnostic and prognostic importance
- They’ll also learn about the clinical profile of 50 patients of STEMI and its complications