HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.

3rd Edition of International Heart Congress

June 05-07,2025 | Hybrid Event

June 05 -07, 2025 | Rome, Italy
Heart Congress 2023

Computational hemodynamic evaluation for postoperative thrombosis risk based on virtual surgery of systemic-to-pulmonary artery shunt

Jiwen Xiong, Speaker at Heart Conferences
Shanghai Jiao Tong University, China
Title : Computational hemodynamic evaluation for postoperative thrombosis risk based on virtual surgery of systemic-to-pulmonary artery shunt

Abstract:

Systemic-to-pulmonary artery shunt is widely used as a palliative operation to treat complex congenital heart disease. Postoperative thrombosis-induced shunt occlusion is a life-threatening complication. Different surgical designs affect the hemodynamic characteristics, which is intimately related to shunt thrombosis. This study aims to explore the effects of different shunt locations and shunt sizes on postoperative hemodynamic parameters related to thrombosis risk, thus to provide reference for preoperative planning and postoperative thrombosis risk assessment. The three-dimensional vascular model was reconstructed based on the patient-specific medical images. A 4mm artificial conduit was interposed virtually between the ascending aorta (or right subclavian artery, or left innominate artery, separately) and pulmonary artery using computer-aided design (CAD). Three virtual models were formed, and named Model 1, Model 2 and Model 3 in sequence. Another two conduits (diameter of 3.5mm and 5mm) were modified on Model 3. Computational fluid dynamics was applied to calculated hemodynamic parameters including wall shear stress (WSS), oscillatory shear index (OSI), particle relative residence time (RRT). The results suggested that the distribution of WSS and OSI of the shunt and pulmonary artery changed with the change of shunt location, but the shunt conduit was always associated with high WSS and high OSI. With the increase of shunt size, the WSS of the shunt decreased and the area of high OSI and high RRT decreased partly, which was not conducive to reducing the potential risk of postoperative thrombosis. The shunt location significantly changes the distribution of hemodynamic parameters related to postoperative thrombosis risk. Comparing with the impacts brought by the change of shunt location, the shunt size has limited effects on the parameters related to thrombosis risk. The evaluation and monitoring of postoperative thrombosis risk cannot be ignored when the shunt size is larger.

Biography:

Dr. Xiong studied Pediatrics at the Shanghai Jiao Tong University, supervised by Prof. Jinlong Liu and received her master degree in June, 2021. She then joined the research group of Prof. Liu at the Institute of Pediatric Translational Medicine and Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center. She mainly focused on the research of computational hemodynamics-based surgery design for congenital heart disease and obtained the position of an Assistant Research Fellow at the same institute. She has published 6 research articles in both SCI(E) and Chinese journals.

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