HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

3rd Edition of International Heart Congress

June 05-07,2025 | Hybrid Event

June 05 -07, 2025 | Rome, Italy
Heart Congress 2023

Clinical and cardiac imaging follow-up of the patients with COVID-19 vaccine-associated myocarditis: A systematic review and meta-analysis

Parham Samimisedeh, Speaker at Heart Conferences
Alborz University of Medical Sciences, Iran (Islamic Republic of)
Title : Clinical and cardiac imaging follow-up of the patients with COVID-19 vaccine-associated myocarditis: A systematic review and meta-analysis

Abstract:

Myocarditis has emerged as a serious adverse event after the COVID-19 vaccination. Our review study summarized the findings of Cardiac MRI and clinical follow-up of the patients with COVID-19 vaccine-associated myocarditis. We systematically searched MEDLINE, Embase, and Scopus databases up to 21 Oct 2022. We included studies performing initial and follow-up cardiac MRIs for patients with COVID-19 vaccine-associated myocarditis. Case reports, as a single series of cases, were combined with the case series using random effect models according to study heterogeneity. Twenty-one case reports/series (n = 109 patients) met our eligibility criteria. At the time of follow-up, myocarditis symptoms were resolved in all patients, but an abnormal Electrocardiography (ECG) and elevated troponin level were detected in 21% (9/43) and 4% (3/71) of them, respectively. Median imaging follow-up times varied from 3 to 6.3 months. On follow-up Cardiac MRI, the persistence of Late Gadolinium Enhancement (LGE) was observed in 74% (95% confidence interval (CI): 66 to 82%), but its extension declined compared to the baseline in almost all patients. Persistent LGE was accompanied by myocardial edema (LGE + and raised T2) in six patients and it was consistent with myocardial fibrosis (LGE without edema) in remained cases (n=67). Mean changes (95% CI) of cardiac MRI left ventricular ejection fraction (LVEF) (%) was +2.96 (+1.78 to +4.14) from baseline. In terms of adverse cardiac events, non-sustained ventricular tachycardia was experienced by two patients during follow-up. In conclusion, although most patients likely experience rapid clinical improvement, cardiac MRI abnormalities, mainly LGE, may persist in a notable proportion of them beyond the acute phase. Three patients had persistently elevated troponin levels that raised concerns about possible ongoing or recurrent myocarditis. Longer follow-up (at least one year from diagnosis) may be required to have a better vision of COVID-19 vaccine related myocarditis prognosis.

Biography:

Dr. Parham Samimisedeh studied Medicine at Alborz University of Medical Sciences, Iran, and graduated as Medical Doctor (M.D) in 2021. Then he joined the research group at the cardiovascular research center, Alborz University of Medical sciences. He has published several articles in the cardiovascular field since beginning his career as a post-doctoral fellowship in 2022. He is interested in interventional cardiology, inflammatory cardiac disease, cardiovascular rehabilitation, and new machine-learning-based technology in the cardiovascular field.

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