Title : Association of plasma endothelin-1 with re-hospitalization due to heart failure in psoriatic patients with coronary artery disease
Abstract:
Background: The plasma big endothelin-1 (big ET-1) plays an important role in endothelial dysfunction and thrombogenesis, and it is closely related to cardiovascular adverse events. However, for patients with psoriasis who have already suffered from coronary artery disease (CAD), whether big ET-1 is independently correlated with prognosis is still uncertain.
Methods: We conducted a retrospective cohort study of consecutive psoriatic patients with CAD between January 2017 and May 2022 in our hospital. The clinical records were collected, and comparisons were made between groups. The Kaplan-Meier survival analysis was used to evaluate the association between variables.
Results: Of the 223 participants, one hundred and fifty-three patients were with elevated big ET-1. The proportions of diabetes, hypertension and hyperlipidemia were not different between the two groups. Compared with patients with normal big ET-1, the levels of hemoglobin (p = 0.007), high-density lipoprotein cholesterol (p = 0.031) and left ventricular ejection fraction (p < 0.001) were lower in patients with elevated big ET-1. After the mean follow-up of 35.26 months, the rates of re-hospitalization due to heart failure were not different between the two groups (p = 0.351). However, in the subgroup analysis, elevated big ET-1 was associated with the re-hospitalization due to heart failure in patients with age < 60 years old (log rank p = 0.048).
Conclusion: In psoriatic patients with CAD, the plasma big ET-1 can independently predict re-hospitalization due to heart failure in patients with age < 60 years old. Moreover, plasma big ET-1 can improve the predictability of a well-established risk score.
Audience Take Away Notes
- In patients with psoriasis and coronary artery disease, elevated endothelin-1 (big ET-1) levels were associated with re-hospitalization due to heart failure in patients with age < 60 years old
- The results contribute to risk stratification in this subset of patients and will provide a clearer understanding of the effect of big ET-1 on the prognosis of these patients
- t is suggested that big ET-1 level should be closely detected in young psoriatic patients concurrent with coronary artery disease, and regular follow-up should be considered to avoid adverse clinical events
