Title : Investigating the effect of a period of aerobic exercise on inflammatory and anti-inflammatory factors in atherosclerosis
Abstract:
An imbalance in the Th1/Th2 immune response, specifically a shift towards Th1 dominance, is associated with increased risk factors for heart disease. This imbalance can be seen in conditions like coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM), where elevated Th1 cytokines and suppressed Th2 cytokines are observed. This suggests that the type of inflammation, driven by Th1 or Th2 responses, may play a crucial role in the development and progression of cardiovascular diseases.
The purpose of this research to compare the level of Th1 cells (IL-2, IFN-?) , Th2 cells(IL-6 , IL-10) and serum Cortisol hormone on midle edge of people.
This is an applied research that its data is gathered by free method. So in order to carry out the research among healthy and volunteer people, 20 of them (weight:78± 4.1 kgs , height: 179 ± 3.59 ms , age: 66 ± 4.38 BMI: 24 ± 1.51) are sorted in TRAINING group (scientific group) and 12 of them (weight:79± 4.62 kgs , height: 181 ± 2.51 ms , age: 65 ± 4.32 BMI: 24 ± 1.63) in non-TRAINING group (control group). The scientific group includes those TRAINING who has at least 6 months of regular aerobic exercise and the control group are the people who haven’t had any sport experience. Blood samples for evaluating the above factors in Elisa method are taken from both groups. Considering that the data were normal, with a T test, the independent student in the meaningful level of (P? 0/005) is examined.
Comparing the average amount of IL-2 , IL-6 , IL-10, IFN-? and serum Cortisol hormone in both groups, the amount of IL-6 and Cortisol hormones in the scientific group has reduced considerably (p<0/05).
The results of this research showed that aerobic exercise changed the balance of Th1/Th2 to TH1. The variations of these cytokines demonstrated the imbalance of Th1 and Th2 cytokines existed in cardiac injuries induced by fine particle. The imbalance of Th1/Th2 cytokines might be one of the mechanisms of immunotoxicity of cardiovascular system induced by ambient fine particles.
